TACI/TNFRSF13B/CVID Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56516

Novus Biologicals, part of Bio-Techne
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NB100-56516
NB100-56516SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

2.0 mg/ml

View all TACI/TNFRSF13B Antibodies »

Product Specifications

Immunogen

This rabbit polyclonal antibody was developed against a synthetic peptide corresponding to amino acids 116-132 of human TACI. Human and mouse TACI amino acid sequences are 65% conserved in the immunogen.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TACI/TNFRSF13B/CVID Antibody

Western Blot: TACI/TNFRSF13B/CVID Antibody [NB100-56516]

Western Blot: TACI/TNFRSF13B/CVID Antibody [NB100-56516]

Western Blot: TACI/TNFRSF13B/CVID Antibody [NB100-56516] - Analysis of A) human spleen, B) mouse spleen, C) human stomach, D) and mouse stomach lysate using TACI antibody at 2 ug/ml.

Applications for TACI/TNFRSF13B/CVID Antibody

Application
Recommended Usage

Immunohistochemistry

reported in multiple pieces of scientific literature

Immunohistochemistry-Paraffin

reported in scientific literature (PMID 22512719)

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

2.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TACI/TNFRSF13B

Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and BlyS (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells (5). Recently two orphan receptors TACI (6) and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-kB, and AP-1. TACI is a type III transmembrane protein, as defined by the lack of a cleaved signal sequence and its N-terminal extracellular exposure. The cDNA codes for 293 amino acids with predicted molecular weight of approx. 32 kDa.

Long Name

Transmembrane Activator and CAML Interactor/Tumor Necrosis Factor Receptor Superfamily Member 13B

Alternate Names

CD267, CVID, TNFRSF13B

Entrez Gene IDs

23495 (Human); 57916 (Mouse)

Gene Symbol

TNFRSF13B

UniProt

NP_036584

Additional TACI/TNFRSF13B Products

Product Documents for TACI/TNFRSF13B/CVID Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TACI/TNFRSF13B/CVID Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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