TAK1 [p Ser439] Antibody (SR2176)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21597

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21597-50ul
NBP3-21597-100ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human, Mouse, Rat

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2176

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TAK1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-TAK1 [Ser439] (Uniprot #: O43318)

Modification

p Ser 439

Specificity

Detects endogenous levels of total phospho-TAK1 [Ser439]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

72 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TAK1 [p Ser439] Antibody (SR2176)

Western Blot: TAK1 [p Ser 439] Antibody (SR2176) [NBP3-21597] -

Western Blot: TAK1 [p Ser 439] Antibody (SR2176) [NBP3-21597] - Western blot analysis using NBP3-21597 in (1) HeLa treated with Calyculin A + IL-1 beta cell lysate; (2) Untreated.

Applications for TAK1 [p Ser439] Antibody (SR2176)

Application
Recommended Usage

Immunoprecipitation

1:50

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TAK1

TAK1 (or MAP3K7) was shown to participate in regulation of transcription by transforming growth factor beta (TGF beta). TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 (TGF b activated kinase 1) MAPKKK in TGF b signal transduction. TAB1 induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF a activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against TNF a induced NFkB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.

Long Name

TGF-beta activated kinase 1

Alternate Names

MAP3K7, TGF1a

Gene Symbol

MAP3K7

Additional TAK1 Products

Product Documents for TAK1 [p Ser439] Antibody (SR2176)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TAK1 [p Ser439] Antibody (SR2176)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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