TAp63 Antibody (TAp63-4.1) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11703

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # TAp63-4.1

Format

BSA Free

Concentration

1 mg/ml

View all TAp63 Antibodies »

Product Summary for TAp63 Antibody (TAp63-4.1) - BSA Free

Immunogen

Recombinant human p63

Epitope

Target epitope is LSDPMW.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Specificity

The mouse monoclonal antibody TAp63-4.1 recognizes TAp63. This antibody does not bind to deltaNp63 isoform of p63.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for TAp63 Antibody (TAp63-4.1) - BSA Free

Western Blot: TAp63 Antibody (TAp63-4.1)BSA Free [NBP3-11703]

Western Blot: TAp63 Antibody (TAp63-4.1)BSA Free [NBP3-11703]

Western Blot: TAp63 Antibody (TAp63-4.1) [NBP3-11703] - Analysis, confirming specificity of mouse monoclonal antibody TAp63-4.1 for TAp63 isoform of p63 protein. Cell lysates from particular transfectants of TAp63alpha, TAp63gamma, deltaNp63alpha, TAp73alpha, and deltaNp73alpha were analysed.

Applications for TAp63 Antibody (TAp63-4.1) - BSA Free

Application
Recommended Usage

Western Blot

1 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TAp63

The p53 family of proteins includes three members, p53, p63, and p73. The protein p63 is encoded by TP63 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp63) or absence (deltaNp63) of an N-terminal transactivation domain. Immunohistochemistry of p63 has a clinical relevance for certain tumor types, but investigations have been hampered by a lack of well characterized antibodies that are specific for p63, do not cross-react with the related p53 and p73 proteins, and allow for discrimination between p63 isoforms TAp63 and deltaNp63 with opposite functional properties.

Alternate Names

p63 Transactivation Domain Isoform, Transactivation p63, Transactivation Tumor protein 63

Gene Symbol

TP63

Additional TAp63 Products

Product Documents for TAp63 Antibody (TAp63-4.1) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TAp63 Antibody (TAp63-4.1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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