Tau [p Ser262] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-82242

Novus Biologicals, part of Bio-Techne
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NB100-82242
NB100-82242-0.025ml
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Simple Western, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all Tau Antibodies »

Product Specifications

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 262 (I-G-SP-T-E).

Modification

p Ser262

Specificity

Detects endogenous levels of Tau only when phosphorylated at serine 262.

Marker

pan-Neuronal Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Tau [p Ser262] Antibody

Simple Western: Tau [p Ser262] Antibody [NB100-82242]

Simple Western: Tau [p Ser262] Antibody [NB100-82242]

Simple Western: Tau [p Ser262] Antibody [NB100-82242] - Simple western analysis of mouse brain tissue (striatum) from 4 month old Tg4150 and wildtype mice. Image courtesy of Dr. Brandi Wasek-Patterson at Baylor Research Institute, Institute of Metabolic Disease.
Tau [p Ser262] Antibody

Western Blot: Tau [p Ser262] Antibody [NB100-82242] -

Western Blot: Tau [p Ser262] Antibody [NB100-82242] - Western blot analysis of lysates from HeLa cells, using NB100-82242. The lane on the left is blocked with the phospho peptide.

Applications for Tau [p Ser262] Antibody

Application
Recommended Usage

ELISA

1:5000

Western Blot

1:500-1:2000

Reviewed Applications

Read 1 review rated 3 using NB100-82242 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% glycerol, 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Tau

Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.

Long Name

Microtubule-Associated Protein Tau

Alternate Names

MAPT, MSTD, MTBT1, Neurofibrillary tangle protein, PPND

Entrez Gene IDs

4137 (Human); 17762 (Mouse); 29477 (Rat)

Gene Symbol

MAPT

UniProt

P10636

Additional Tau Products

Product Documents for Tau [p Ser262] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Tau [p Ser262] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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