TBC1D4 [p Thr642] Antibody (SR1272)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22607

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22607-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1272

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TBC1D4 Antibodies »

Product Summary for TBC1D4 [p Thr642] Antibody (SR1272)

Immunogen

A synthesized peptide derived from human phospho-TBC1D4 [Thr642] (Uniprot #: O60343)

Modification

p Thr 642

Specificity

Detects endogenous levels of total phospho-TBC1D4 [Thr642]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

180 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TBC1D4 [p Thr642] Antibody (SR1272)

Western Blot: TBC1D4 [p Thr 642] Antibody (SR1272) [NBP3-22607] -

Western Blot: TBC1D4 [p Thr 642] Antibody (SR1272) [NBP3-22607] - Western blot analysis using NBP3-22607 in 293T treated with insulin cell lysate.

Applications for TBC1D4 [p Thr642] Antibody (SR1272)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TBC1D4

AS160, also known as TBC1D4, is a 160 kDa Akt substrate that plays a critical role in regulating insulin-stimulated exocytosis of glucose transporter GLUT4. AS-160 contains a Rab GTPase-activating protein domain (GAP), suggesting its potential role in membrane trafficking. Insulin-stimulated phosphorylation of AS160 on threonine 642 is critical for mediating GLUT4 translocation in fat and muscle cells, via inactivation of Rab GAP function. Phosphorylation of Thr642 is also important in mediating TBC1D4 redistribution from low density microsomes to the cytosol in adipocytes.

Alternate Names

Akt substrate of 160 kDa, AS160Acrg embryonic lethality minimal region ortholog, DKFZp779C0666, KIAA0603TBC (Tre-2, BUB2, CDC16) domain-containing protein, TBC1 domain family member 4, TBC1 domain family, member 4

Gene Symbol

TBC1D4

Additional TBC1D4 Products

Product Documents for TBC1D4 [p Thr642] Antibody (SR1272)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TBC1D4 [p Thr642] Antibody (SR1272)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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