TBC1D4 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81935

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all TBC1D4 Antibodies »

Product Summary for TBC1D4 Antibody - BSA Free

Immunogen

TBC1D4 antibody was raised against an 19 amino acid peptide near the carboxy terminus of human TBC1D4 . The immunogen is located within amino acids 1190 - 1240 of TBC1D4. Amino Acid Squence: ETLEKLERANSQLKRQNMD

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse: (89%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

140 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TBC1D4 Antibody - BSA Free

Immunohistochemistry: TBC1D4 Antibody - BSA Free [NBP2-81935]

Immunohistochemistry: TBC1D4 Antibody - BSA Free [NBP2-81935]

Immunohistochemistry: TBC1D4 Antibody [NBP2-81935] - Analysis of TBC1D4 in human prostate tissue with TBC1D4 antibody at 10 ug/ml.

Applications for TBC1D4 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

10 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TBC1D4

AS160, also known as TBC1D4, is a 160 kDa Akt substrate that plays a critical role in regulating insulin-stimulated exocytosis of glucose transporter GLUT4. AS-160 contains a Rab GTPase-activating protein domain (GAP), suggesting its potential role in membrane trafficking. Insulin-stimulated phosphorylation of AS160 on threonine 642 is critical for mediating GLUT4 translocation in fat and muscle cells, via inactivation of Rab GAP function. Phosphorylation of Thr642 is also important in mediating TBC1D4 redistribution from low density microsomes to the cytosol in adipocytes.

Alternate Names

Akt substrate of 160 kDa, AS160Acrg embryonic lethality minimal region ortholog, DKFZp779C0666, KIAA0603TBC (Tre-2, BUB2, CDC16) domain-containing protein, TBC1 domain family member 4, TBC1 domain family, member 4

Gene Symbol

TBC1D4

Additional TBC1D4 Products

Product Documents for TBC1D4 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TBC1D4 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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