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TBK1 Antibody (108A429)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27935

Novus Biologicals, part of Bio-Techne
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NBP3-27935

Key Product Details

Species Reactivity

Human, Mouse, Rat, Porcine, Bovine, Canine, Equine, Hamster, Monkey, Primate, Rabbit

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 108A429

Concentration

1 mg/ml

Product Specifications

Immunogen

TBK1 antibody was raised against a synthetic peptide corresponding to amino acids 563 - 577 of TBK1 (Human).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for TBK1 Antibody (108A429)

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:1000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS, 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TBK1

NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).

Long Name

TANK Binding Kinase 1

Alternate Names

FTDALS4, NAK, NFKB-Activating Kinase

Gene Symbol

TBK1

UniProt

Additional TBK1 Products

Product Documents for TBK1 Antibody (108A429)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TBK1 Antibody (108A429)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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