TBK1 [p Ser172] Antibody (SR2251)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21592

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21592-100ul
NBP3-21592-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human, Mouse, Rat

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2251

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TBK1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-TBK1 [Ser172] (Uniprot #: Q9UHD2)

Modification

p Ser172

Specificity

Detects endogenous levels of total phospho-TBK1 [Ser172]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TBK1 [p Ser172] Antibody (SR2251)

Western Blot: TBK1 [p Ser 172] Antibody (SR2251) [NBP3-21592] -

Western Blot: TBK1 [p Ser 172] Antibody (SR2251) [NBP3-21592] - Western blot analysis using NBP3-21592 in (1) HeLa cell lysate; (2) HeLa cell treated with Calyculin A .

Applications for TBK1 [p Ser172] Antibody (SR2251)

Application
Recommended Usage

Immunoprecipitation

1:50

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TBK1

NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).

Long Name

TANK Binding Kinase 1

Alternate Names

FTDALS4, NAK, NFKB-Activating Kinase

Gene Symbol

TBK1

Additional TBK1 Products

Product Documents for TBK1 [p Ser172] Antibody (SR2251)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TBK1 [p Ser172] Antibody (SR2251)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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