TCR alpha Antibody (3A8)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-65265

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse (Negative), Rat (Negative)

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 3A8

Concentration

0.1 mg/ml

View all TCR alpha Antibodies »

Product Specifications

Immunogen

Human TCR ALPHA

Reactivity Notes

Reacts with Human. Does not react with Mouse or Rat.

Specificity

Reacts with the alpha chain constant region found on all alpha beta TCR bearing T-lymphocytes. It reacts with 92-98% of all CD3 + peripheral blood lymphocytes.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for TCR alpha Antibody (3A8)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Immunoprecipitation

1:10-1:500
Application Notes
It has been reported that this antibody does not work in Flow Cytometry.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

<0.1% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TCR alpha

The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain. T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci.

Alternate Names

C), D, FLJ22602, J, MGC117436, MGC22624, MGC23964, MGC71411, T cell receptor alpha locus, T-cell antigen receptor, alpha polypeptide, T-cell receptor, alpha (V, TCRA, TCRD, TRA

Entrez Gene IDs

28755 (Human); 21473 (Mouse); 290071 (Rat)

Gene Symbol

TRA

UniProt

P01848 (Human)

Additional TCR alpha Products

Product Documents for TCR alpha Antibody (3A8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TCR alpha Antibody (3A8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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