TDP-43/TARDBP Antibody (3H8) [DyLight 488]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-92695G

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Product Datasheet / COA / SDS

View Available Conjugates

Conjugate

Catalog #

Unconjugated

NBP1-92695

Alexa Fluor 350

NBP1-92695AF350

Alexa Fluor 405

NBP1-92695AF405

Alexa Fluor 488

NBP1-92695AF488

Alexa Fluor 532

NBP1-92695AF532

Alexa Fluor 594

NBP1-92695AF594

Alexa Fluor 647

NBP1-92695AF647

Alexa Fluor 700

NBP1-92695AF700

Alexa Fluor 750

NBP1-92695AF750

Biotin

NBP1-92695B

CoraFluor 1

NBP1-92695CL1

DyLight 350

NBP1-92695UV

DyLight 405

NBP1-92695V

DyLight 550

NBP1-92695R

DyLight 594

NBP1-92695DL594

DyLight 650

NBP1-92695C

DyLight 680

NBP1-92695FR

DyLight 755

NBP1-92695IR

FITC

NBP1-92695F

HRP

NBP1-92695H

Janelia Fluor 525

NBP1-92695JF525

Janelia Fluor 549

NBP1-92695JF549

Janelia Fluor 585

NBP1-92695JF585

Janelia Fluor 635

NBP1-92695JF635

Janelia Fluor 646

NBP1-92695JF646

Janelia Fluor 669

NBP1-92695JF669

mFluor Violet 450 SE

NBP1-92695MFV450

mFluor Violet 500 SE

NBP1-92695MFV500

mFluor Violet 610 SE

NBP1-92695MFV610

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bovine, Equine

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry Free-Floating, Immunohistochemistry-Paraffin, Immunoprecipitation, Knockout Validated, Western Blot

Label

DyLight 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG₁ Clone # 3H8

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TDP-43/TARDBP Antibodies »

Product Summary for TDP-43/TARDBP Antibody (3H8) [DyLight 488]

Immunogen

Full length recombinant human TDP43 expressed in and purified from E. coli, epitope in peptide HNSNRQLERSGRFGGNPGGF, amino acids 264-283 of the human sequence.

Localization

Nucleus. Note: In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Description

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Applications for TDP-43/TARDBP Antibody (3H8) [DyLight 488]

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry Free-Floating

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Knockout Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: TDP-43/TARDBP

TARDBP, also known as TAR DNA binding protein, is a DNA and RNA-binding protein which regulates transcription and splicing. TARDBP is also involved in the regulation of CFTR splicing and promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TARD-BP may also be involved in microRNA biogenesis, apoptosis and cell division. TARDBP can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat.

Long Name

TAR DNA-binding Protein 43

Alternate Names

ALS10, TARDBP, TDP43

Gene Symbol

TARDBP

Additional TDP-43/TARDBP Products

Product Documents for TDP-43/TARDBP Antibody (3H8) [DyLight 488]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for TDP-43/TARDBP Antibody (3H8) [DyLight 488]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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