TDP1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB100-81643

Novus Biologicals, part of Bio-Techne
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NB100-81643
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all TDP1 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 75 and 125 of human tyrosyl-DNA phosphodiesterase 1 using the numbering given in entry NP_001008744.1 (GeneID 55775).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TDP1 Antibody - BSA Free

Immunoprecipitation: TDP1 Antibody [NB100-81643]

Immunoprecipitation: TDP1 Antibody [NB100-81643]

Immunoprecipitation: TDP1 Antibody [NB100-81643] - Detection of Human TDP1 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-TDP1 antibody NB100-81643 used for IP at 3 mcg/mg lysate. TDP1 was also immunoprecipitated by rabbit anti-TDP1 antibody NB100-81642, which recognizes an upstream epitope. Detection: Chemiluminescence with an exposure time of 10 seconds.

Applications for TDP1 Antibody - BSA Free

Application
Recommended Usage

Immunoprecipitation

2 - 5 ug/mg lysate
Application Notes
Immunoprecipitation. It is not recommended for western analysis.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TDP1

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Alternate Names

EC 3.1.4, EC 3.1.4.-, FLJ11090, MGC104252, SCAN1, Tyr-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1

Entrez Gene IDs

55775 (Human)

Gene Symbol

TDP1

UniProt

NP_001008744.1 (Human)

Additional TDP1 Products

Product Documents for TDP1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TDP1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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