TERF2IP Antibody (78B356.1)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56526

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 78B356.1

Concentration

0.5 mg/ml

View all TERF2IP Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding amino acids 212-235 of human Rap1 was used to immunize mice.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for TERF2IP Antibody (78B356.1)

Western Blot: TERF2IP Antibody (78B356.1) [NB100-56526]

Western Blot: TERF2IP Antibody (78B356.1) [NB100-56526]

Western Blot: TERF21P Antibody (78B356.1) [NB100-56526] - Western blot analysis of A431 (A), HEK293 (B) and HeLa (C) lysates (35ug per lane, RIPA buffer) using TERF21P antibody (NB100-56526) at 0.1ug/ml. Band observed at ~60kDa.

Applications for TERF2IP Antibody (78B356.1)

Application
Recommended Usage

Western Blot

0.1-1 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TERF2IP

Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

Alternate Names

dopamine receptor interacting protein 5, Dopamine receptor-interacting protein 5, DRIP5, hRap1, RAP1 homolog, RAP1TERF2-interacting telomeric protein 1, Repressor/activator protein 1 homolog, telomeric repeat binding factor 2, interacting protein, telomeric repeat-binding factor 2-interacting protein 1, TRF2-interacting telomeric protein 1, TRF2-interacting telomeric RAP1 protein

Entrez Gene IDs

54386 (Human)

Gene Symbol

TERF2IP

UniProt

Q9NYB0 (Human)

Additional TERF2IP Products

Product Documents for TERF2IP Antibody (78B356.1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TERF2IP Antibody (78B356.1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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