TGF-beta RII Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-29951

Novus Biologicals, part of Bio-Techne
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NBP3-29951
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Key Product Details

Species Reactivity

Human

Applications

Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TGF-beta RII Antibodies »

Product Specifications

Immunogen

Between 475 and 525

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TGF-beta RII Antibody

TGF-beta RII Antibody

Immunoprecipitation:TGF-beta RII AntibodyNBP3-29951] -

Immunoprecipitation:TGF-beta RII AntibodyNBP3-29951] -Detection of human TGFBR2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) prepared using NETN buffer from Hep-G2 cells. Antibodies: Affinity purified rabbit anti-TGFBR2 antibody NBP3-29951 (lot NBP3-29951-1) used for IP at 6 µg per reaction. TGFBR2 was inefficiently immunoprecipitated by rabbit anti-TGFBR2.. For blotting immunoprecipitated TGFBR2, A304-414A was used at 1 µg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Applications for TGF-beta RII Antibody

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Tris-citrate/phosphate buffer, pH 7 to 8

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TGF-beta RII

TGF beta Receptor II is a total of three members of the TGFbeta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor (TGFbeta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFbeta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFbeta type I receptor proteins designated ALK-5 (TbetaR-1) and TSR-1, respectively.

Long Name

Transforming Growth Factor beta Receptor II

Alternate Names

TGF-bRII, TGFbetaRII, TGFBR2

Gene Symbol

TGFBR2

Additional TGF-beta RII Products

Product Documents for TGF-beta RII Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TGF-beta RII Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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