Thyroid Peroxidase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-80670

Novus Biologicals, part of Bio-Techne
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NBP1-80670
NBP1-80670-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human, Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Thyroid Peroxidase Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Thyroid Peroxidase Antibody

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670]

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670]

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670] - Staining in human thyroid gland and cerebral cortex tissues using anti-TPO antibody. Corresponding TPO RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670]

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670]

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670] - Staining of human cerebral cortex shows low expression as expected.
Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670]

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670]

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670] - Staining of human thyroid gland shows high expression.

Applications for Thyroid Peroxidase Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

Reported in scientific literature (PMID: 31010838)
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Thyroid Peroxidase

Thyroid Peroxidase encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined. [provided by RefSeq]

Alternate Names

EC 1.11.1, MSA, TDH2A, thyroid microsomal antigen, thyroid peroxidase, thyroperoxidase, TPXEC 1.11.1.8

Entrez Gene IDs

7173 (Human)

Gene Symbol

TPO

UniProt

P07202 (Human)

Additional Thyroid Peroxidase Products

Product Documents for Thyroid Peroxidase Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Thyroid Peroxidase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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