Tie-2 Antibody [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-69753B

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Simple Western, Western Blot

Label

Biotin

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Tie-2 Antibodies »

Product Summary for Tie-2 Antibody [Biotin]

Immunogen

A genomic peptide made to an internal region of the human TIE2 protein (within residues 250-400). [Swiss-Prot Q02763]

Localization

Membrane, single pass type-1 membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Tie-2 Antibody [Biotin]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Tie-2

The endothelium-specific receptor tyrosine kinase 2 binds and interacts with angiogenic proteins. In acute inflammation, TIE2 signals vascular endothelial cells to stop early leakiness in vessels. This interaction depends partly upon VEGF, PLGF and PDGF. In pregnancy, vascular remodeling is initiated and mediated by VEGF and PLGF; however, recent studies demonstrate that failure of effective vascular remodeling in pre-eclampsia is associated with the erroneously low production of soluble TIE2. Following cerebral stroke, TIE2 production is also critical for appropriate vascular endothelial cell migration and differentiation in response and repair mechanisms. In most cases, damage caused by diabetes, stroke, hypoxia and other cellular insults to vascular endothelial cells is repaired through effective balance of TIE2 with other angiogenic proteins. When the ratio of these proteins is inappropriate, and TIE2 expression decreases, vascular damage occurs.

Long Name

Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains 2

Alternate Names

CD202b, TEK, Tie2

Gene Symbol

TEK

Additional Tie-2 Products

Product Documents for Tie-2 Antibody [Biotin]

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Tie-2 Antibody [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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