TIMP-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38700

Novus Biologicals, part of Bio-Techne
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NBP2-38700
NBP2-38700-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TIMP-1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: WNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TIMP-1 Antibody

Immunohistochemistry-Paraffin: TIMP-1 Antibody [NBP2-38700]

Immunohistochemistry-Paraffin: TIMP-1 Antibody [NBP2-38700]

Immunohistochemistry-Paraffin: TIMP-1 Antibody [NBP2-38700] - Staining of human prostate shows strong cytoplasmic positivity in glandular cells.
TIMP-1 Antibody

Immunohistochemistry-Paraffin: TIMP-1 Antibody [NBP2-38700] -

Immunohistochemistry-Paraffin: TIMP-1 Antibody [NBP2-38700] -Staining of human duodenum shows no positivity in glandular cells as expected.
TIMP-1 Antibody

Immunohistochemistry-Paraffin: TIMP-1 Antibody [NBP2-38700] -

Immunohistochemistry-Paraffin: TIMP-1 Antibody [NBP2-38700] -Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
View 1 more images

Applications for TIMP-1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TIMP-1

Tissue inhibitor of metalloproteinases 1 (TIMP1) and Tissue inhibitor of metalloproteinases 2 (TIMP 2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, active form of 72kDa Type IV collagenase (also known as MMP2 or gelatinase A), and latent and active forms 92kDa Type IV collagenase (also known as MMP0 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumour cells and normal placental trophoblast cells. TIMP1 is produced in low (pg/ml) levels by most cell types. Treatment of cells with the phorbol ester TPA stimulates production of TIMP1 in some cell types, but the low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.

Long Name

Tissue Inhibitors of Metalloproteinases 1

Alternate Names

TIMP1

Gene Symbol

TIMP1

UniProt

P01033

Additional TIMP-1 Products

Product Documents for TIMP-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TIMP-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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