Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 67N17F8

Concentration

0.5 mg/ml

View all TLR2 Antibodies »

Product Specifications

Immunogen

Within the range of amino acids 227-398 of human TLR2 were used as the immunogen for the antibody.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for TLR2 Antibody (67N17F8)

Western Blot: TLR2 Antibody (67N17F8) [NBP2-25244]

Western Blot: TLR2 Antibody (67N17F8) [NBP2-25244]

Western Blot: TLR2 Antibody (67N17F8) [NBP2-25244] - Analysis of TLR2 partial recombinant protein (A), transfected cell lysate (B), and control HEK293T lysate (C) using TLR2 antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: TLR2 Antibody (67N17F8) [NBP2-25244]

Immunohistochemistry-Paraffin: TLR2 Antibody (67N17F8) [NBP2-25244]

Immunohistochemistry-Paraffin: TLR2 Antibody (67N17F8) [NBP2-25244] - FFPE human breast stained with TLR2 antibody at 5 ug/ml.

Applications for TLR2 Antibody (67N17F8)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1:100-1:2000
Application Notes
Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TLR2

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-B.[2] Recent research indicates that in the intestine, TLR2 functionality is essential for regulating the expression of CYP1A1, which is a key enzyme in detoxication of carcinogenic polycyclic aromatic hydrocarbons such as benzo(a)pyrene.

Long Name

Toll-like Receptor 2

Alternate Names

CD282

Gene Symbol

TLR2

UniProt

NP_003255.2 (Human)

Additional TLR2 Products

Product Documents for TLR2 Antibody (67N17F8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TLR2 Antibody (67N17F8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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