TLR5 Antibody (10D8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26285

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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NBP3-26285-100ul
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 10D8

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TLR5 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from Human TLR5 [UniProt O60602]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TLR5 Antibody (10D8)

TLR5 Antibody (10D8)

Western Blot: TLR5 Antibody (10D8) [NBP3-26285] -

Western Blot: TLR5 Antibody (10D8) [NBP3-26285] - Positive Western Blot detected in: THP-1 whole cell lysate, RAW264.7 whole cell lysate, U-251 whole cell lysate, K562 whole cell lysate.
All lanes: TLR5 Antibody at 1: 1000
Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution.
Predicted band size: 98 kDa
Observed band size: 98 kDa

Applications for TLR5 Antibody (10D8)

Application
Recommended Usage

Western Blot

1:500-1:5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, and 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: TLR5

The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens.

Long Name

Toll-like Receptor 5

Alternate Names

TIL-3

Gene Symbol

TLR5

Additional TLR5 Products

Product Documents for TLR5 Antibody (10D8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TLR5 Antibody (10D8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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