TMEM97 Antibody [FITC]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-30436F

Novus Biologicals, part of Bio-Techne
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NBP1-30436
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Primate (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TMEM97 Antibodies »

Product Summary for TMEM97 Antibody [FITC]

Immunogen

Synthetic peptide made to an internal portion of the human TMEM97 protein (within residues 105-155.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: crab-eating macaque (98%). Mouse reactivity reported in scientific literature (PMID: 30594810).

Localization

Membrane; Multi-pass membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for TMEM97 Antibody [FITC]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: TMEM97

TMEM97 (transmembrane protein 97 or protein MAC30) is a member of IGFBP/insulin-like growth factor-binding protein family and is implicated in several biological processes wherein it acts through its regulatory effects on IGF activity. It is a multi-pass membrane protein which is localized in nuclear and cell membranes, RER and lysosomes, and is expressed in several normal tissues including brain, lung, heart, skeletal muscles, testis, ovary, and pregnant uterus. TMEM97 was originally identified as overexpressed in meningiomas, however, later it was found to exhibit altered expression in different types of cancers. The absence or downregulation of TMEM97 expression in pancreatic cancer suggests that it may acts as a tumor suppressor in pancreatic cancer. Contrastingly, its expression is stronger in breast, esophageal, stomach, colon, and oral squamous cell cancers than the corresponding normal tissues. Its physiological function is largely unknown, however, it has been suggested to implicate in cellular proliferation/differentiation and regulation of cholesterol homeostasis.

Long Name

Sigma intracellular receptor 2

Alternate Names

MAC30, S2R, Sigma-2 receptor, Sigma2 receptor

Gene Symbol

TMEM97

Additional TMEM97 Products

Product Documents for TMEM97 Antibody [FITC]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TMEM97 Antibody [FITC]

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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