TopBP1 Antibody (6D12)

Novus Biologicals, part of Bio-Techne | Catalog # H00011073-M04-100ug

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 6D12

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TopBP1 Antibodies »

Product Specifications

Immunogen

TOPBP1 (NP_008958, 1327 a.a. ~ 1435 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. LLQSGGAKVLPGHSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for TopBP1 Antibody (6D12)

Western Blot: TopBP1 Antibody (6D12) [H00011073-M04-100ug]

Western Blot: TopBP1 Antibody (6D12) [H00011073-M04-100ug]

Western Blot: TopBP1 Antibody (6D12) [H00011073-M04-100ug] - Detection against Immunogen (37.73 KDa) .
Western Blot: TopBP1 Antibody (6D12) [H00011073-M04-100ug]

Western Blot: TopBP1 Antibody (6D12) [H00011073-M04-100ug]

Western Blot: TopBP1 Antibody (6D12) [H00011073-M04-100ug] - Monoclonal antibody (M04), clone 6D12. Western Blot analysis of TOPBP1 expression in Jurkat.
ELISA: TopBP1 Antibody (6D12) [H00011073-M04-100ug]

ELISA: TopBP1 Antibody (6D12) [H00011073-M04-100ug]

ELISA: TopBP1 Antibody (6D12) [H00011073-M04-100ug] - Detection limit for recombinant GST tagged TOPBP1 is 0.03 ng/ml as a capture antibody.

Applications for TopBP1 Antibody (6D12)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: TopBP1

DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.

Long Name

DNA Topoisomerase II Binding Protein 1

Alternate Names

TOP2BP1

Entrez Gene IDs

11073 (Human)

Gene Symbol

TOPBP1

OMIM

607760 (Human)

UniProt

NP_008958 (Human)

Additional TopBP1 Products

Product Documents for TopBP1 Antibody (6D12)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TopBP1 Antibody (6D12)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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