TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103)

Novus Biologicals, part of Bio-Techne | Catalog # NB110-93504

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NB110-93504
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Validated:

Human, Rat

Predicted:

Canine (100%), Mouse (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 2103

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TR alpha/NR1A1 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. Accession # P10827

Reactivity Notes

It is anticipated that the antibody will react with canine, mouse and non-human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Specificity

Specific for endogenous levels of the ~50 kDa TR-alpha 1 and the ~58 kDa TR-alpha 2 proteins.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103)

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103) [NB110-93504]

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103) [NB110-93504]

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103) [NB110-93504] - Analysis of Rat Hippocampal lysate showing specific immunolabeling of the -50k and the -58k TR-a2 protein.

Applications for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103)

Application
Recommended Usage

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TR alpha/NR1A1

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR alpha1, TR alpha2, TR beta1 and TR beta2. TR alpha1, TR beta1 and TR beta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Long Name

Thyroid Hormone Receptor alpha

Alternate Names

NR1A1, THRA, v-ErbA1

Entrez Gene IDs

21833 (Mouse); 81812 (Rat)

Gene Symbol

THRA

UniProt

P10827 (Human)

Additional TR alpha/NR1A1 Products

Product Documents for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.