TRAILR2/TNFRSF10B Antibody (102)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-89513

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP2-89513-100ul
NBP2-89513-50ul
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 102

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TRAIL R2/TNFRSF10B Antibodies »

Product Specifications

Immunogen

This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAILR2/TNFRSF10B extracellular domain (Met 1-Glu 182; Accession#: NP_003833.4).

Specificity

No cross-reactivity in ELISA with: Human TNFRSF10A / CD261 / APO2 Human TNFRSF10D / CD264 / DCR2 / TRAILR4

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for TRAILR2/TNFRSF10B Antibody (102)

Flow Cytometry: TRAILR2/TNFRSF10B Antibody (102) [NBP2-89513]

Flow Cytometry: TRAILR2/TNFRSF10B Antibody (102) [NBP2-89513]

Flow Cytometry: TRAILR2/TNFRSF10B Antibody (102) [NBP2-89513] - Analysis of Human TNFRSF10B(CD262) expression on Jurkat cells. Cells were stained with purified anti-Human TNFRSF10B(CD262), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Applications for TRAILR2/TNFRSF10B Antibody (102)

Application
Recommended Usage

ELISA

1:5000-1:10000

Flow Cytometry

1:25-1:100
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAIL R2/TNFRSF10B

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-2). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Long Name

TRAIL Receptor 2

Alternate Names

CD262, DR5, TNFRSF10B, TRAILR2

Gene Symbol

TNFRSF10B

Additional TRAIL R2/TNFRSF10B Products

Product Documents for TRAILR2/TNFRSF10B Antibody (102)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRAILR2/TNFRSF10B Antibody (102)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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