TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-80070

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # TR2.21

Format

BSA Free

Concentration

1 mg/ml

View all TRAIL R2/TNFRSF10B Antibodies »

Product Specifications

Immunogen

Recombinant human TRAILR2/TNFRSF10B (DR5).

Specificity

Recognizes human TRAILR2/TNFRSF10B. Does not cross-react with human TRAIL-R1, -R3 or -R4.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free [NBP2-80070]

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free [NBP2-80070]

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (TR2.21) [NBP2-80070] - Negative control.
Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free [NBP2-80070]

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free [NBP2-80070]

Immunohistochemistry-Paraffin: TRAILR2/TNFRSF10B Antibody (TR2.21) [NBP2-80070] - Immunohistochemistry detection of endogenous TRAIL-R2 in paraffin-embedded human carcinoma tissues (colon, tonsil) using mAb to TRAIL-R2 (TR2.21).

Applications for TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free

Application
Recommended Usage

Immunohistochemistry

20 ug/mL

Immunohistochemistry-Paraffin

20 ug/mL
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 10% glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAIL R2/TNFRSF10B

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-2). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Long Name

TRAIL Receptor 2

Alternate Names

CD262, DR5, TNFRSF10B, TRAILR2

Gene Symbol

TNFRSF10B

Additional TRAIL R2/TNFRSF10B Products

Product Documents for TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRAILR2/TNFRSF10B Antibody (TR2.21) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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