TRAILR3/TNFRSF10C Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56445

Novus Biologicals, part of Bio-Techne
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NB100-56445
NB100-56445SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all TRAIL R3/TNFRSF10C Antibodies »

Product Specifications

Immunogen

This antibody was developed against a synthetic peptide corresponding to amino acids 155-168 ([BLAST]CSSSVSNPRNWLFL[/BLAST]) of mouse DcTrailR1; GenBank no: NP_077252.2.

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 31555275).

Specificity

The amino acid sequence used is 92% homologous in DcTrailR2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRAILR3/TNFRSF10C Antibody

Western Blot: TRAILR3/TNFRSF10C Antibody [NB100-56445]

Western Blot: TRAILR3/TNFRSF10C Antibody [NB100-56445]

Western Blot: TRAIL R3/TNFRSF10C Antibody [NB100-56445] - Analysis of TRAIL R3/TNFRSF10C 15 ug of mouse spleen cell lysate using this antibody.

Applications for TRAILR3/TNFRSF10C Antibody

Application
Recommended Usage

Western Blot

1-3 ug/ml
Application Notes
In mouse spleen, a 20 kDa band is observed.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAIL R3/TNFRSF10C

Mouse DcTRAILR1 and DcTRAILR2 (decoy TRAIL receptors 1 and 2) proteins are receptors for TRAIL according to ligand-receptor binding assays (Schneider et al. 2001). However, overexpression does not cause NF-kB activation or apoptosis, as would be expected of a TRAIL receptor. These observations led researchers to refer to these receptors as decoys. It is thought that cells that express decoy TRAIL receptor decoys at high levels relative to actual TRAIL receptors may use decoys as protection against the cytotoxic action of TRAIL (reviewed in Bouralexis et al. 2005). Additional analysis of these two murine TRAIL decoy receptors should help facilitate the understanding of the complex biology underlying TRAIL ligand/receptor interactions. DcTRAILR1 is an amino acid protein of 176 amino acids (GenBank no: NP-077252.2). DcTRAILR2 is an amino acid protein of 198 amino acids (GenBank no: AAN87807.1).f

Long Name

TRAIL Receptor 3

Alternate Names

CD263, DcR1, TNFRSF10C, TRAILR3

Gene Symbol

TNFRSF10C

Additional TRAIL R3/TNFRSF10C Products

Product Documents for TRAILR3/TNFRSF10C Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRAILR3/TNFRSF10C Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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