Transglutaminase 2/TGM2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24470

Novus Biologicals, part of Bio-Techne
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NBP2-24470SS
NBP2-24470
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Chimpanzee (93%), Monkey (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Simple Western, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all Transglutaminase 2/TGM2 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 600-650 of human Transglutaminase 2 was used as the immunogen.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Transglutaminase 2/TGM2 Antibody

Western Blot: Transglutaminase 2/TGM2 Antibody [NBP2-24470]

Western Blot: Transglutaminase 2/TGM2 Antibody [NBP2-24470]

Western Blot: Transglutaminase 2/TGM2 Antibody [NBP2-24470] - Analysis of extracts from K562 cells using Transglutaminase 2 antibody at 1:100.
Immunohistochemistry-Paraffin: Transglutaminase 2/TGM2 Antibody [NBP2-24470]

Immunohistochemistry-Paraffin: Transglutaminase 2/TGM2 Antibody [NBP2-24470]

Immunohistochemistry-Paraffin: Transglutaminase 2/TGM2 Antibody [NBP2-24470] - Analysis of a FFPE tissue section of human liver using 1:200 dilution of Transglutaminase 2/TGM2 antibody (NBP2-24470). The staining was developed using HRP labeled anti-rabbit secondary antibody and DAB reagent, and nuclei of cells were counter-stained with hematoxylin.
Western Blot: Transglutaminase 2/TGM2 Antibody [NBP2-24470]

Western Blot: Transglutaminase 2/TGM2 Antibody [NBP2-24470]

Western Blot: Transglutaminase 2/TGM2 Antibody [NBP2-24470] - Analysis of Transglutaminase 2 in A) BxPC-3 cell lysate using NBP2-24470 at 2.0 ug/ml and B) MCF-7 negative control cell lysate.
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Applications for Transglutaminase 2/TGM2 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2 ug/ml

Simple Western

1:50

Western Blot

2-5 ug/ml
Application Notes
In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS and 0.05% BSA

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Transglutaminase 2/TGM2

Transglutaminase 2 is historically a member of the transglutaminase family that catalyzes a calcium-dependent acyl transfer reaction between peptide bound glutamine and a suitable primary amine.The protein is known to participate in all-trans-retinoic acid mediated signaling events as a G-protein and transamidate targets such as RhoA and the retinoblastoma gene product. The action of transglutaminase 2 stabilizes proteins by conferring mechanical resistance and protection from proteolysis. The protein is expressed intracellularly and secreted on the cell surface where it interacts with proteins in the extracellular matrix and aids in anchoring cells to basement membranes. Recently, transglutaminase 2 has been identified as an important factor that interacts with fibronectin in the extracellular matrix at the cell membrane and provides survival signals and inhibits anoikis in fibroblasts. The protein is expressed in human endothelial cells. The human transglutaminase 2 gene is localized in the chromosomal region 20q12. Transcript variants encoding two different isoforms have been found for this gene. Deficiency of the protein results in early-onset diabetes type 2.

Alternate Names

TGC, TGM2, Transglutaminase 2, tTG

Gene Symbol

TGM2

UniProt

P21980

Additional Transglutaminase 2/TGM2 Products

Product Documents for Transglutaminase 2/TGM2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Transglutaminase 2/TGM2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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