TREK 1 Antibody [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NB110-41535V

Novus Biologicals, part of Bio-Techne
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NB110-41535V
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Bovine

Applications

ICC/IF (Negative), Immunohistochemistry (Negative), Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TREK 1 Antibodies »

Product Summary for TREK 1 Antibody [DyLight 405]

Immunogen

A synthetic peptide made to an N-terminal region of human TREK 1 (within residues 1-100). [Swiss-Prot# Q9NRT2]

Reactivity Notes

88% sequence identity with rat protein.

Localization

Membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for TREK 1 Antibody [DyLight 405]

Application
Recommended Usage

Western Blot

1:1000
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: TREK 1

TREK 1 (KCNK2 or two pore potassium channel TPKC1) belongs to two pore domain potassium channel (TC 1.A.1.8) family and it is a TWIK related K+ channel that acts as a background channel producing time/voltage-independent background current which drives the membrane potential toward the K+ equilibrium potential thereby affecting input resistance. TREK1 is characterized by mechanosensitivity, heat sensitivity, G-protein regulation, and activation by lipids, arachidonic acid, and volatile anesthetics such as chloroform, halothane and isoflurane. TREK1 is widely expressed in brain and genetic ablation has revealed involvement of this channel in depression, neuroprotection, pain perception, and ischemia-precipitated epilepsy. TREK1 gene inactivation produces mice with decreased sensitivity to volatile anesthetics, impaired PUFA-mediated neuroprotection and altered pain perception, depression-resistant phenotype and alteration in the efficacy of GPCR-associated cascade producing NO that leads to major endothelial dysfunction.

Long Name

Potassium channel subfamily K member 2

Alternate Names

KCNK2, TREK, TREK1

Gene Symbol

KCNK2

Additional TREK 1 Products

Product Documents for TREK 1 Antibody [DyLight 405]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TREK 1 Antibody [DyLight 405]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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