TRIAD3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56891

Novus Biologicals, part of Bio-Techne
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NB100-56891
NB100-56891SS
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all TRIAD3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of human TRIAD3 between amino acids 350-400.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRIAD3 Antibody

Western Blot: TRIAD3 Antibody [NB100-56891]

Western Blot: TRIAD3 Antibody [NB100-56891]

Western Blot: TRIAD3 Antibody [NB100-56891] - Analysis of TRIAD3 in human (A) Brain; (B) Heart; (C) Small Intestine; (D) Kidney; (E) Liver; (F) Lung; (G) Skeletal Muscle; (H) Pancreas; (I) Spleen; (J) Ovary; (K) Testis using NB100-56891 at 1 ug/mL.

Applications for TRIAD3 Antibody

Application
Recommended Usage

Western Blot

1 - 3 ug/mL

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS, 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRIAD3

Official Gene Symbol: TRIAD3 Gene ID: 54476 (Human) Gene Map Locus: 7p22.1 (Human) TRIADs are novel zinc finger proteins characterized by the presence of Cysteine rich TRIAD domain consisting of DRIL motif flanked by 2 RING fingers. TRIAD3, a 56KDa protein, is a novel member of this family. It contains 4 RLD domains in the centre and a proline-rich domain at the C-terminus. Localized in the cytoplasm, it interacts with RIP and inhibits TNF and IL1-induced NF-kappaB activation pathways. Reports suggest TRIAD3 acts as an E3-ubiquitin-protein ligase and promotes ubiquitination and degradation of TLR4 and TLR9, thereby regulating TLR signaling. It also interacts with HIV type I Vif protein and interferes in the early events of HIV-1 replication.

Alternate Names

EC 6.3.2.-, ring finger protein 216Ubiquitin-conjugating enzyme 7-interacting protein 1, Triad domain-containing protein 3, TRIAD3Zinc finger protein inhibiting NF-kappa-B, U7I1, UBCE7IP1ubiquitin conjugating enzyme 7 interacting protein 1, ZINE3 ubiquitin-protein ligase RNF216

Entrez Gene IDs

54476 (Human)

Gene Symbol

RNF216

UniProt

NP_996999 (Human)

Additional TRIAD3 Products

Product Documents for TRIAD3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRIAD3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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