Troponin I Type 1 (slow skeletal) Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90923

Novus Biologicals, part of Bio-Techne
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NBP1-90923
NBP1-90923-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse

Predicted:

Rat (96%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Troponin I Type 1 (slow skeletal) Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: PEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLSALQDLCREL

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23435261). Mouse reactivity reported in scientific literature (PMID: 27035161).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Troponin I Type 1 (slow skeletal) Antibody

Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923]

Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923]

Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923] - Staining of human Skeletal muscle shows strong cytoplasmic positivity in myocytes.
Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923]

Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923]

Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923] - Staining of human skeletal muscle shows distinct cytoplasmic positivity in subsets of myocytes.
Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923]

Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923]

Immunohistochemistry-Paraffin: Troponin I Type 1 (slow skeletal) Antibody [NBP1-90923] - Staining of human Endometrium shows no cytoplasmic positivity in glandular cells as expected.
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Applications for Troponin I Type 1 (slow skeletal) Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:50-1:200

Western Blot

1:100-1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, WB, IHC-P reactivity reported in (PMID: 27035161).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Troponin I Type 1 (slow skeletal)

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. (provided by RefSeq)

Alternate Names

DKFZp451O223, slow-twitch isoform, SSTNI, TNN1, troponin I type 1 (skeletal, slow), troponin I, skeletal, slow, troponin I, slow skeletal muscle

Gene Symbol

TNNI1

Additional Troponin I Type 1 (slow skeletal) Products

Product Documents for Troponin I Type 1 (slow skeletal) Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Troponin I Type 1 (slow skeletal) Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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