Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptionalregulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPARgamma signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.

Long Name

TSC22 Domain Family, Member 1

Alternate Names

Egr5, TGFB1I4, TSC22D1

Gene Symbol

TSC22D1

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Product Documents for TSC22/TSC22D1 Antibody (002) [Janelia Fluor® 635]

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Product Specific Notices for TSC22/TSC22D1 Antibody (002) [Janelia Fluor® 635]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TSC22/TSC22D1 Antibody (002) [Janelia Fluor® 635]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-90141JF635

Key Product Details

Species Reactivity

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Product Specifications

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Applications for TSC22/TSC22D1 Antibody (002) [Janelia Fluor® 635]

ELISA

Formulation, Preparation, and Storage

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Background: TSC22