Tyk2 Antibody (5A4)

Novus Biologicals, part of Bio-Techne | Catalog # H00007297-M02

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Product Datasheet / COA / SDS

Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 5A4

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tyk2 Antibodies »

Product Specifications

Immunogen

TYK2 (AAH14243, 276 a.a. ~ 375 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. PVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAFGQPADRPREPLWA

Specificity

TYK2 - tyrosine kinase 2

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Tyk2 Antibody (5A4)

Western Blot: Tyk2 Antibody (5A4) [H00007297-M02]

Western Blot: Tyk2 Antibody (5A4) [H00007297-M02] - TYK2 monoclonal antibody (M02), clone 5A4 Analysis of TYK2 expression in Hela S3 NE.

Immunocytochemistry/ Immunofluorescence: Tyk2 Antibody (5A4) [H00007297-M02]

Immunocytochemistry/Immunofluorescence: Tyk2 Antibody (5A4) [H00007297-M02] - Analysis of monoclonal antibody to TYK2 on HeLa cell. Antibody concentration 10 ug/ml.

Immunohistochemistry-Paraffin: Tyk2 Antibody (5A4) [H00007297-M02]

Immunohistochemistry-Paraffin: Tyk2 Antibody (5A4) [H00007297-M02] - Analysis of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human leiomyosarcoma. Antibody concentration 3 ug/ml.

Applications for Tyk2 Antibody (5A4)

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Antibody reactivity against cell lysate for WB. It has also been used for IF, IHC-P and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Tyk2

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Long Name

Protein tyrosine kinase 2

Alternate Names

EC 2.7.10, EC 2.7.10.2, JTK1, non-receptor tyrosine-protein kinase TYK2, tyrosine kinase 2

Entrez Gene IDs

7297 (Human)

Gene Symbol

TYK2

OMIM

176941 (Human)

UniProt

AAH14243 (Human)

Additional Tyk2 Products

Product Documents for Tyk2 Antibody (5A4)

Product Datasheets

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COA

SDS

Product Specific Notices for Tyk2 Antibody (5A4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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