Tyk2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-32450

Novus Biologicals, part of Bio-Techne
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NBP1-32450
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tyk2 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human TYK2. The exact sequence is proprietary.

Reactivity Notes

Mouse (88%), Rat (89%), Pig (88%), Bovine (87%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

134 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Tyk2 Antibody

Western Blot: Tyk2 Antibody [NBP1-32450]

Western Blot: Tyk2 Antibody [NBP1-32450]

Western Blot: Tyk2 Antibody [NBP1-32450] - Whole cell extract (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with TYK2 antibody [C1C3] diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
Immunocytochemistry/ Immunofluorescence: Tyk2 Antibody [NBP1-32450]

Immunocytochemistry/ Immunofluorescence: Tyk2 Antibody [NBP1-32450]

Immunocytochemistry/Immunofluorescence: Tyk2 Antibody [NBP1-32450] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution.
Western Blot: Tyk2 Antibody [NBP1-32450]

Western Blot: Tyk2 Antibody [NBP1-32450]

Western Blot: Tyk2 Antibody [NBP1-32450] - Various whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with TYK2 antibody [C1C3] diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Applications for Tyk2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Tyk2

Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.

Long Name

Protein tyrosine kinase 2

Alternate Names

EC 2.7.10, EC 2.7.10.2, JTK1, non-receptor tyrosine-protein kinase TYK2, tyrosine kinase 2

Gene Symbol

TYK2

Additional Tyk2 Products

Product Documents for Tyk2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Tyk2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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