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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # U-16

Format

BSA Free

Concentration

1.0 mg/ml

Product Specifications

Immunogen

Native human uPA

Epitope

Binds to the B-chain of uPA

Specificity

It is specific for human uPA. No reaction with human tissue plasminogen activator (tPA) when tested by ELISA, immunoblotting and enzyme inhibition and no reaction with any other human plasma proteins when tested by immunoblotting. Binds single and two-chain uPA and uPA/PAI-1 complexes. A reaction is seen with LMW-uPA but not with amino terminal fregment (ATF).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for u-Plasminogen Activator/Urokinase Antibody (U-16) - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Western Blot

1:100-1:2000
Application Notes
ELISA: NBP1-05160 can be used in ELISA. (1) WB: NBP1-05160 reacts with non-reduced uPA but not with reduced uPA in Western blotting. IHC: NBP1-05160 is recommended for flowcytometry and immunoflourescence studies and can be used on frozen sections in immunohistochemistry applications.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.01 M phosphate buffer, pH 7.4, containing 0.14 M NaCl

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: u-Plasminogen Activator (uPA)/Urokinase

Urokinase plasminogen activator (uPA) is a serine protease. It converts the abundant proenzyme plasminogen to active plasmin and plays a key role in cancer invasion and a variety of tissue remodeling processes such as wound healing, mammary gland involution and placental development (1-3). Elevated levels of uPA are associated with poor prognosis in many types of cancer (2-5).

Long Name

Urokinase-type Plasminogen Activator

Alternate Names

PLAU, uPA, uPlasminogen Activator, Urokinase

Gene Symbol

PLAU

Additional u-Plasminogen Activator (uPA)/Urokinase Products

Product Documents for u-Plasminogen Activator/Urokinase Antibody (U-16) - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for u-Plasminogen Activator/Urokinase Antibody (U-16) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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