UBE2N/Ubc13 Antibody (JG38-68)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-76876

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP2-76876
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # JG38-68

Concentration

1 mg/ml

View all UBE2N/Ubc13 Antibodies »

Product Summary for UBE2N/Ubc13 Antibody (JG38-68)

Immunogen

Recombinant protein within Human UBE2N/Ubc13 aa 1-93 / 152. (SwissProt: P61088 Human; SwissProt: P61089 Mouse; SwissProt: Q9EQX9 Rat)

Localization

Nucleus. Cytoplasm.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

17 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for UBE2N/Ubc13 Antibody (JG38-68)

Western Blot: UBE2N/Ubc13 Antibody (JG38-68) [NBP2-76876]

Western Blot: UBE2N/Ubc13 Antibody (JG38-68) [NBP2-76876]

Western Blot: UBE2N/Ubc13 Antibody (JG38-68) [NBP2-76876] - Western blot analysis of Ube2N on different lysates using anti-Ube2N antibody at 1/1,000 dilution.Positive control:Lane 1: Daudi Lane 2: SH-SY-5YLane 3: Mouse spleen Lane 4: Rat spleen

Applications for UBE2N/Ubc13 Antibody (JG38-68)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

TBS (pH7.4), 0.05% BSA, 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UBE2N/Ubc13

UBC13 is a member of the E2 ubiquitin-conjugating enzyme family also known as Ubiquitin-conjugating enzyme E2 N, Ubiquitin-protein ligase N, Ubiquitin carrier protein N and Bendless-like ubiquitin-conjugating enzyme. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. UBC13 forms a heterodimer with UBE2V2 which then catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. UBC13 also mediates transcriptional activation of target genes and plays a role in the control of progress through the cell cycle and differentiation, as well as error-free DNA repair. UBC13 also contributes to the survival of cells after DNA damage.

Alternate Names

BLU, UBC13, UbcH13, UBE2N

Gene Symbol

UBE2N

Additional UBE2N/Ubc13 Products

Product Documents for UBE2N/Ubc13 Antibody (JG38-68)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for UBE2N/Ubc13 Antibody (JG38-68)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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