Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all UCMA Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human UCMA. The immunogen is located within the last 50 amino acids of UCMA. Amino Acid Squence: WHYDGLHPSYLYNRHHT

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (81%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

19 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for UCMA Antibody - BSA Free

Western Blot: UCMA AntibodyBSA Free [NBP1-76321]

Western Blot: UCMA AntibodyBSA Free [NBP1-76321]

Western Blot: UCMA Antibody [NBP1-76321] - Analysis of UCMA in SW1353 cell lysate with UCMA antibody at 2.5 ug/mL.
Western Blot: UCMA AntibodyBSA Free [NBP1-76321]

Western Blot: UCMA AntibodyBSA Free [NBP1-76321]

Western Blot: UCMA Antibody [NBP1-76321] - SW1353 cell lysate with UCMA antibody at (A) 2.5 and (B) 5 ug/ml.

Applications for UCMA Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

2.5-5 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UCMA

UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.

Alternate Names

C10orf49, chromosome 10 open reading frame 49, Gla-rich protein, GRP, unique cartilage matrix-associated protein, upper zone of growth plate and cartilage matrix associated

Gene Symbol

UCMA

UniProt

NP_660357 (Human)

Additional UCMA Products

Product Documents for UCMA Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for UCMA Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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