Vanilloid R1/TRPV1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-98890

Novus Biologicals, part of Bio-Techne
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NB100-98890
NB100-98890-0.025ml
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Key Product Details

Species Reactivity

Rabbit

Applications

Validated:

Immunohistochemistry, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Sheep

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Vanilloid R1/TRPV1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide from amino acid region 600-650 of rabbit Vanilloid R1/TRPV1 conjugated to an immunogenic carrier protein was used as the antigen.

Clonality

Polyclonal

Host

Sheep

Applications for Vanilloid R1/TRPV1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:300-1:2000

Western Blot

1:300-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Unpurified

Reconstitution

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the sample size is provided in reconstituted format.

Formulation

Lyophilized from whole antisera

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Vanilloid R1/TRPV1

FUNCTION: Receptor-activated non-selective calcium permanent cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH

Long Name

Vanilloid Receptor 1/Transient Receptor Potential Cation Channel 1

Alternate Names

Capsaicin Receptor, TRPV1, VanilloidR1, VR1

Entrez Gene IDs

100008926 (Rabbit)

Gene Symbol

TRPV1

UniProt

Q6RX08 (Rabbit)

Additional Vanilloid R1/TRPV1 Products

Product Documents for Vanilloid R1/TRPV1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Vanilloid R1/TRPV1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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