Vanilloid R1/TRPV1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-98897

Novus Biologicals, part of Bio-Techne
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NB100-98897
NB100-98897-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human, Rat, Porcine

Cited:

Human, Rat, Porcine

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Vanilloid R1/TRPV1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide from human Vanilloid R1/TRPV1 conjugated to blue carrier protein was used as the antigen.

Reactivity Notes

Porcine reactivity reported in scientific literature (PMID: 29351450). Rat reactivity reported in scientific literature (PMID: 22579820). The antigen displays sequence identity for other non-tested species including Canine.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Vanilloid R1/TRPV1 Antibody

Western Blot: Vanilloid R1/TRPV1 Antibody [NB100-98897]

Western Blot: Vanilloid R1/TRPV1 Antibody [NB100-98897]

Western Blot: Vanilloid R1/TRPV1 Antibody [NB100-98897] - HPV status and EphrinB1 contribute to neurite outgrowth. Western blot analysis of whole tumor lysates from mice bearing SCC1 or SCC1 EphrinB1 tumors. Western blots repeated at least n = 4 times with technical replicates. Western blots have been cropped for clarity and conciseness. Image collected and cropped by CiteAb from the following publication (www.nature.com/articles/s41467-018-06640-0) licensed under a CC-BY license.
Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98897]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98897]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98897] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to 3d cytoplasmic loop TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1): whole serum (NB100-98897) at 1: 300 dilution incubated overnight at 4C.
Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98897]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98897]

Immunohistochemistry-Paraffin: Vanilloid R1/TRPV1 Antibody [NB100-98897] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to 3d cytoplasmic loop TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1): whole serum (NB100-98897) at 1: 300 dilution incubated overnight at 4C.

Applications for Vanilloid R1/TRPV1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:2000

Immunohistochemistry-Paraffin

1:2000

Western Blot

1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Unpurified

Reconstitution

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the sample size is provided in reconstituted format.

Formulation

Lyophilized from whole antisera

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Vanilloid R1/TRPV1

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. FUNCTION: Receptor-activated non-selective calcium permanent cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.

Long Name

Vanilloid Receptor 1/Transient Receptor Potential Cation Channel 1

Alternate Names

Capsaicin Receptor, TRPV1, VanilloidR1, VR1

Entrez Gene IDs

7442 (Human); 193034 (Mouse); 83810 (Rat)

Gene Symbol

TRPV1

UniProt

Q8NER1 (Human)

Additional Vanilloid R1/TRPV1 Products

Product Documents for Vanilloid R1/TRPV1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Vanilloid R1/TRPV1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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