Von Hippel Lindau Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00007428-D01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all VHL Antibodies »

Product Specifications

Immunogen

VHL (ENSP00000344757, 1 a.a. - 172 a.a.) full-length human protein. MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Quality control test: Antibody reactive against mammalian transfected lysate.

Scientific Data Images for Von Hippel Lindau Antibody

Western Blot: Von Hippel Lindau Antibody [H00007428-D01P]

Western Blot: Von Hippel Lindau Antibody [H00007428-D01P]

Western Blot: Von Hippel Lindau Antibody [H00007428-D01P] - Analysis of VHL expression in mouse lung.
Western Blot: Von Hippel Lindau Antibody [H00007428-D01P]

Western Blot: Von Hippel Lindau Antibody [H00007428-D01P]

Western Blot: Von Hippel Lindau Antibody [H00007428-D01P] - Analysis of VHL expression in transfected 293T cell line by VHL polyclonal antibody.Lane 1: VHL transfected lysate(19.70 KDa).Lane 2: Non-transfected lysate.

Applications for Von Hippel Lindau Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
It has been used for WB.

Reviewed Applications

Read 1 review rated 5 using H00007428-D01P in the following applications:

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: VHL

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Long Name

Von Hippel-Lindau Tumor Suppressor

Alternate Names

Protein G7, pVHL

Gene Symbol

VHL

UniProt

ENSP00000344757 (Human)

Additional VHL Products

Product Documents for Von Hippel Lindau Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Von Hippel Lindau Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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