WASP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87827

Novus Biologicals, part of Bio-Techne
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NBP1-87827
NBP1-87827-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (90%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all WASP Antibodies »

Product Summary for WASP Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKK

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (88%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for WASP Antibody

Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827]

Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827]

Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827] - Analysis in human lymph node and kidney tissues using NBP1-87827 antibody. Corresponding WASP RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827]

Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827]

Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827] - Staining of human spleen shows strong cytoplasmic positivity in cells in red pulp and cells in white pulp.
Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827]

Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827]

Immunohistochemistry-Paraffin: WASP Antibody [NBP1-87827] - Staining of human appendix shows high expression.
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Applications for WASP Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: WASP

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Long Name

Wiskott-Aldrich Syndrome Protein

Alternate Names

Thrombocytopenia 1, WAS

Gene Symbol

WAS

Additional WASP Products

Product Documents for WASP Antibody

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Certificate of Analysis

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Product Specific Notices for WASP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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