WT1 Antibody (WT1/1434R) [Janelia Fluor® 646]

Janelia Fluor 646

Monoclonal Rabbit IgG Clone # WT1/1434R

Please see the vial label for concentration. If unlisted please contact technical services.

Recombinant human full-length WT1 protein (Uniprot: P19544 )

Nucleus and cytoplasm, Shuttles between nucleus and Cytoplasm

Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilms Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors.WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.

Wilm's Tumor & Mesothelial Marker

Monoclonal

Rabbit

IgG

Protein A or G purified

50mM Sodium Borate

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.