XRCC3 Antibody (SR1724)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22361

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22361-100ul
NBP3-22361-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Flow Cytometry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1724

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all XRCC3 Antibodies »

Product Summary for XRCC3 Antibody (SR1724)

Immunogen

A synthesized peptide derived from human XRCC3 (Uniprot #: O43542)

Specificity

Detects endogenous levels of total XRCC3

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

42 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for XRCC3 Antibody (SR1724)

Western Blot: XRCC3 Antibody (SR1724) [NBP3-22361] -

Western Blot: XRCC3 Antibody (SR1724) [NBP3-22361] - Western blot analysis using NBP3-22361 in HeLa cell lysate.

Applications for XRCC3 Antibody (SR1724)

Application
Recommended Usage

Flow Cytometry

1:50

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: XRCC3

XRCC3, also known as DNA repair protein XRCC3, X-ray repair cross-complementing protein 3, and CMM6, belongs to the RecA family and the RAD51 subfamily. XRCC3 plays a role in the homologous recombination repair (HRR) pathway of double-stranded DNA. The pathway is responsible for repairing chromosomal fragmentation, translocations, and deletions. Additionally, XRCC3 is also involved in regulating the mitochondrial DNA copy number in the presence of oxidative stress in the presence of RAD51 and RAD51C. XRCC3 is a functional compliment to Chinese hamster irs1SF. Rare microsatellite polymorphisms in the XRCC3 gene have been associated with cancer in patients with radiosensitivity. Defects of the XRCC3 gene have also been linked to breast cancer and cutaneous malignant melanoma type 6 (CMM6).

Alternate Names

CMM6, DNA repair protein XRCC3, X-ray repair complementing defective repair in Chinese hamster cells 3, X-ray repair cross-complementing protein 3

Gene Symbol

XRCC3

Additional XRCC3 Products

Product Documents for XRCC3 Antibody (SR1724)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for XRCC3 Antibody (SR1724)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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