ZEB1 Antibody [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-13159V

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Primate

Applications

Immunocytochemistry/ Immunofluorescence, Simple Western, Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ZEB1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to an C-terminal portion of the human ZEB1 protein (between residues 1087-1124).

Localization

Nucleus and cytoplasm.

Marker

Mesenchymal Cells Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for ZEB1 Antibody [DyLight 405]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: ZEB1

ZEB1, also known as AREB6, is a zinc finger transcription factor encoding protein that represses T-lymphocyte-specific interleukin-2 (IL-2) gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (PMID: 1840704). ZEB1 is expressed in both skeletal and heart muscle, but is not found in the liver. ZEB1 mutations can cause posterior polymorphous corneal dystrophy type 3 (PPCD3) as well as corneal dystrophy Fuchs endothelial type 6 (FECD6). The former is a condition characterized by the metaplasia and overgrowth of corneal endothelial cells thus leading to an increased risk for glaucoma. The latter ocular disorder, FECD6, leads to reduced vision and pain and is caused by loss of endothelium of the central cornea. ZEB1 antibodies are useful tools for studying certain degenerative ocular diseases.

Long Name

Zinc Finger E-box Binding Homeobox 1

Alternate Names

AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP

Gene Symbol

ZEB1

Additional ZEB1 Products

Product Documents for ZEB1 Antibody [DyLight 405]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ZEB1 Antibody [DyLight 405]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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