Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14629

Novus Biologicals, part of Bio-Techne
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Key Product Details

Sample Type & Volume Required Per Well

Serum, Plasma, Cell culture supernatant (100 ul)

Sensitivity

12 pg/ml

Assay Range

62.5-2000 pg/ml

View all Fas Ligand/TNFSF6 ELISA Kits »

Product Specifications

Assay Type

Sandwich ELISA

Kit Type

ELISA Kit (Colorimetric)

Reactivity

Human

Specificity

Recognizes both natural and recombinant soluble human Fas Ligand/TNFSF6. No cross reactivity with other human soluble molecules.

Description

Incubation: 3 hours 45 minutes

Precision

Intra-Assay Precision (Precision within an assay) CV% < 4.5

Scientific Data Images for Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric)

ELISA: Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric) [NBP3-14629]

ELISA: Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric) [NBP3-14629]

ELISA: Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric) [NBP3-14629] - Example of Human Fas Ligand/TNFSF6 Standard Curve.

Kit Contents for Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric)

  • Biotinylated secondary antibody
  • Buffers
  • Controls (where applicable)
  • Detailed procedure.
  • Pre-coated strip plates
  • Standards
  • Stop reagents
  • Streptavidin-HRP
  • TMB

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Fas Ligand/TNFSF6

Fas / APO-1 (CD95) is an important member of the tumour necrosis factor (TNF) superfamily involved in membrane-mediated apoptosis. Ligation of Fas by Fas Ligand (Fas-L) or an anti-Fas cross-linking antibody, triggers activation of the caspase cascade. Functional impairment of the Fas / Fas-L system is associated with the development and progression of malignancies. Fas gene mutations have been suggested to have a role in testicular germ cell tumours. Tumour cells frequently exhibit de novo expression of Fas Ligand (Fas-L), which plays a significant role in local tissue destruction, metastatic spread, and immune escape of the tumor cells. The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas-L system. Fas is believed to be involved in various autoimmune diseases including, ulcerative colitis, Graves disease, and rheumatoid arthritis. Fas expression on gastric epithelial cells in patients infected with H.Pylori is responsible for the accelerated apoptosis of the cells. Serum Fas-L concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension.

Alternate Names

CD178, CD95L, FASLG, TNFSF6

Gene Symbol

FASLG

Additional Fas Ligand/TNFSF6 Products

Product Documents for Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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