Fas Ligand/TNFSF6 Products
Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells.
A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintenance of immune-privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor-infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity.
Products:
97 results for "Fas Ligand/TNFSF6" in Products
97 results for "Fas Ligand/TNFSF6" in Products
Fas Ligand/TNFSF6 Products
Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells.
A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintenance of immune-privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor-infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity.
Products:
Control for use with Human and Non-Human Primate Fas Ligand/TNFSF6 Simple Plex Cartridge Kit
| Applications: | Ctrl, Simple Plex |
| Sensitivity: | 5.1 pg/mL |
| Applications: | ELISA |
| Assay Range: | 15.6 - 1,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma) |
| Source: | CHO |
| Accession #: | Q53ZZ1 |
| Applications: | BA |
| Sensitivity: | 3.9 pg/mL |
| Applications: | ELISA |
| Assay Range: | 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #14C2 |
| Applications: | ELISA, Flow, IP, WB (-) |
![Flow Cytometry: Fas Ligand/TNFSF6 Antibody (14C2) - BSA Free [NB100-63072]](https://resources.bio-techne.com/images/products/Fas-Ligand-TNFSF6-Antibody-14C2-Flow-Cytometry-NB100-63072-img0003.jpg "Flow Cytometry: Fas Ligand/TNFSF6 Antibody (14C2) - BSA Free [NB100-63072]")
| Reactivity: | Mouse |
| Details: | Rat IgM Monoclonal Clone #A11 |
| Applications: | IHC, ICC/IF, Flow |
![Immunohistochemistry-Paraffin: Fas Ligand/TNFSF6 Antibody (A11) [NBP1-97519]](https://resources.bio-techne.com/images/products/Fas-Ligand-Antibody-A11-Immunohistochemistry-Paraffin-NBP1-97519-img0001.jpg "Immunohistochemistry-Paraffin: Fas Ligand/TNFSF6 Antibody (A11) [NBP1-97519]")
| Assay Range: | 31.2 - 2,000 pg/mL |
| Applications: | ELISA |
| Source: | CHO |
| Accession #: | P41047 |
| Applications: | BA |
| Assay Range: | 15.6 - 1,000 pg/mL |
| Applications: | ELISA |
Clone NOK-1 was used by HLDA to establish CD designation.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #NOK-1 |
| Applications: | WB, ICC/IF, Flow, IP |
![Flow Cytometry: Fas Ligand/TNFSF6 Antibody (NOK-1) - BSA Free [NBP3-09151]](https://resources.bio-techne.com/images/products/Fas-Ligand-TNFSF6-Antibody-NOK-1-Flow-Cytometry-NBP3-09151-img0002.jpg "Flow Cytometry: Fas Ligand/TNFSF6 Antibody (NOK-1) - BSA Free [NBP3-09151]")
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Fas Ligand/TNFSF6 Antibody [NBP2-49160]](https://resources.bio-techne.com/images/products/Fas-Ligand-TNFSF6-Antibody-Immunohistochemistry-Paraffin-NBP2-49160-img0004.jpg "Immunohistochemistry-Paraffin: Fas Ligand/TNFSF6 Antibody [NBP2-49160]")
| Source: | NS0 |
| Accession #: | Q544E9 |
| Applications: | BA, BA |
| Applications: | AC |
| Applications: | WB |
![Western Blot: Fas Ligand/TNFSF6 Overexpression Lysate [NBL1-10600]](https://resources.bio-techne.com/images/products/Fas-Ligand-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-10600-img0002.jpg "Western Blot: Fas Ligand/TNFSF6 Overexpression Lysate [NBL1-10600]")
| Applications: | ELISA |
![ELISA: Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric) [NBP3-14629]](https://resources.bio-techne.com/images/products/Human-Fas-Ligand-TNFSF6-ELISA-Kit-Colorimetric-ELISA-NBP3-14629-img0001.jpg "ELISA: Human Fas Ligand/TNFSF6 ELISA Kit (Colorimetric) [NBP3-14629]")
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #100419 |
| Applications: | ELISA, Flow, B/N, ELISA(Cap), ELISA(Det) |
| Reactivity: | Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #100419 |
| Applications: | Flow, Neut |
Simple Plex Human Fas Ligand/TNFSF6 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Neut |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #154911 |
| Applications: | WB, IHC, mIF |
| Reactivity: | Mouse |
| Details: | Rat IgG1 Monoclonal Clone #101626 |
| Applications: | WB, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
