IL-6R alpha Antibody Pair [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79562

Novus Biologicals, part of Bio-Techne
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Key Product Details

Assay Type

Sandwich ELISA

Assay Range

6.25-400 pg/ml (example only; lot dependent)

Sensitivity

6.25 pg/ml (example only; lot dependent)

Reactivity

Mouse

View all IL-6R alpha ELISA Kits »

Product Specifications

Description

Solid Phase sandwich ELISA for the quantitative determination of Mouse IL-6R alpha.

Sample Volume Required

100 ul

Conjugate

HRP

Scientific Data Images for IL-6R alpha Antibody Pair [HRP]

Sandwich ELISA: IL-6R alpha Antibody Pair [HRP] [NBP2-79562] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Kit Contents for IL-6R alpha Antibody Pair [HRP]

  • Rabbit Monoclonal Capture Antibody: (Catalog # NBP2-90512)
  • Rabbit Polyclonal Detection Antibody (HRP-conjugated)
  • Standard

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: IL-6R alpha

IL-6 R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.

Long Name

Interleukin 6 Receptor alpha

Alternate Names

CD126, IL-6 R alpha, IL-6Ra, IL6R, IL6R alpha

Gene Symbol

IL6R

Additional IL-6R alpha Products

Product Documents for IL-6R alpha Antibody Pair [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for IL-6R alpha Antibody Pair [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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