IL-6R alpha Products
IL-6R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6R alpha.
IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.
Products:
327 results for "IL-6R alpha" in Products
327 results for "IL-6R alpha" in Products
IL-6R alpha Products
IL-6R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6R alpha.
IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.
Products:
| Source: | Sf 21 (baculovirus) |
| Accession #: | P08887.1 |
| Applications: | BA |
| Sensitivity: | 15.1 pg/mL |
| Applications: | ELISA |
| Assay Range: | 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma, Urine) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #17506 |
| Applications: | WB, Flow, CyTOF-ready, Neut |
| Sensitivity: | 0.07 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.188 - 12 ng/mL (Cell Culture Supernates, Serum, Heparin Plasma) |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-ready, Neut |
Simple Plex Human IL-6R alpha assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Assay Range: | 15.6 - 1,000 pg/mL |
| Applications: | ELISA |
| Source: | HEK293 |
| Accession #: | P08887 (IL-6 R alpha) & P05231 (IL-6) |
| Applications: | BA |
| Assay Range: | 46.9 - 3,000 pg/mL |
| Applications: | ELISA |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Source: | NS0 |
| Accession #: | P22272 |
| Applications: | Bind |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Assay Range: | 78.1 - 5,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Mouse |
| Details: | Rat IgG1 Monoclonal Clone #255820 |
| Applications: | WB, ICC |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #255821 |
| Applications: | Flow, CyTOF-ready, ICC |
Recombinant Monoclonal Antibody For Research Use Only
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu203 |
| Applications: | ELISA, Flow, Block |
Simple Plex Non-Human Primate IL-6R alpha assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #17506R |
| Applications: | WB, Flow, CyTOF-ready, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow |
| Source: | NS0 |
| Accession #: | P22272 (IL-6 R alpha ) & P08505 (IL-6) |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #17506 |
| Applications: | Flow |
Recombinant Monoclonal Antibody For Research Use Only
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu137 |
| Applications: | Flow, CyTOF-ready, Neut |
Control for use with Human and Non-Human Primate IL-6R alpha Simple Plex Cartridge Kit
| Applications: | Ctrl, Simple Plex |