Serpin E1/PAI-1 Antibody Pair [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79560

Novus Biologicals, part of Bio-Techne
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Key Product Details

Assay Type

Sandwich ELISA

Assay Range

46.88-3000 pg/ml (example only; lot dependent)

Sensitivity

46.88 pg/ml (example only; lot dependent)

Reactivity

Human

View all Serpin E1/PAI-1 ELISA Kits »

Product Specifications

Description

Solid Phase sandwich ELISA for the quantitative determination of Human Serpin E1/PAI-1.

Sample Volume Required

100 ul

Conjugate

HRP

Scientific Data Images for Serpin E1/PAI-1 Antibody Pair [HRP]

Sandwich ELISA: Serpin E1/PAI-1 Antibody Pair [HRP] [NBP2-79560] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Kit Contents for Serpin E1/PAI-1 Antibody Pair [HRP]

  • Mouse Monoclonal Capture Antibody
  • Rabbit Monoclonal Detection Antibody (HRP-conjugated): (Catalog # NBP2-89393)
  • Standard

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: Serpin E1/PAI-1

PAI-1 and PAI-2 (for plasminogen activator inhibitor-1 and -2) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 have been shown to regulate uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage, resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. uPA is a serine proteinase that is a member of the trypsin family. It is responsible for the cleavage of plasminogen at the Arg-Val bond to produce plasmin. uPA consists of two chains designated A and B. The A chain can be cleaved, resulting in low and high molecular mass forms of uPA.

Long Name

Plasminogen Activator Inhibitor

Alternate Names

Nexin, PAI-1, PAI1, PLANH1

Gene Symbol

SERPINE1

Additional Serpin E1/PAI-1 Products

Product Documents for Serpin E1/PAI-1 Antibody Pair [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Serpin E1/PAI-1 Antibody Pair [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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