BDY FL Lenalidomide

Name: BDY FL Lenalidomide
Brand: Tocris Bioscience
SKU: 7857

Tocris Bioscience, part of Bio-Techne | Catalog # 7857

COA / SDS

Fluorescent cereblon ligand

Key Product Details

Description:	Fluorescent cereblon ligand
Chemical Name:	3-(5,5-Difluoro-7,9-dimethyl-5H-5λ⁴,6λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexyl)propanamide
Purity:	≥95% (HPLC)
Molecular Weight:	632.52

View Full Technical Details for BDY FL Lenalidomide

Technical Data
Citations

Biological Activity for BDY FL Lenalidomide

BDY FL Lenalidomide is a fluorescent cereblon ligand. It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC^® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 506 and 508 nm, respectively.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Optical Data for BDY FL Lenalidomide

Emission Color	Green
λ_abs	506 nm
λ_em	508 nm
Closest Laser line	488 nm
Cell Permeable	Yes
Application	TR-FRET and FP Assays
Alternative For	BDY FL Thalidomide

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer

Technical Data for BDY FL Lenalidomide

M. Wt	632.52
Formula	C₃₃H₃₉BF₂N₆O₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	RCUBMUCPIXRRKQ-UHFFFAOYSA-N
Smiles	O=C(CCC1N2C(C3=C(C2)C(NCCCCCCNC(CCC4=CC=C5N4[B-](F)([N+]6=C(C=C(C6=C5)C)C)F)=O)=CC=C3)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BDY FL Lenalidomide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.33	10

Preparing Stock Solutions for BDY FL Lenalidomide

The following data is based on the product molecular weight 632.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.81 mL	79.05 mL	158.10 mL
0.5 mM	3.16 mL	15.81 mL	31.62 mL
1 mM	1.58 mL	7.90 mL	15.81 mL
5 mM	0.32 mL	1.58 mL	3.16 mL

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References for BDY FL Lenalidomide

References are publications that support the biological activity of the product.

Wang Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol. 2021 PMID: 34035522