FURA-2AM

Name: FURA-2AM
Brand: Tocris Bioscience
SKU: 2220

Tocris Bioscience, part of Bio-Techne | Catalog # 2220

(3)

Citations (7)

COA / SDS

Fluorescent Ca2+ indicator

Key Product Details

Chemical Name:	2-[6-[bis[2-[(Acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]-2-benzofuranyl]-5-oxazolecarboxylic acid (acetyloxy)methyl ester
Purity:	≥95%
Molecular Weight:	1001.85 kDa

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Technical Data
Citations / Reviews (3)

Biological Activity for FURA-2AM

FURA-2AM is a fluorescent ratiometric Ca²⁺ indicator (K_d Ca²⁺ = 145 nM). FURA-2AM is selective for Ca²⁺ over other divalent cations Mg²⁺, Zn²⁺, Fe²⁺ and Mn²⁺. FURA-2AM binds to free intracellular calcium and is used to determine [Ca²⁺]_i concentration.

This product is typically prepared in DMSO. F 127 (Cat. No. 6253) for the solubilization of FURA-2AM is also available.

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Technical Data for FURA-2AM

M. Wt	1001.85 kDa
Formula	C₄₄H₄₇N₃O₂₄
Storage	Store at -20°C
Purity	≥95%
CAS Number	108964-32-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for FURA-2AM

References are publications that support the biological activity of the product.

Bayliss A, Evans P Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS ONE, 2013;8(11):e80833. 2013 PMID: 24265838
Grynkiewicz et al. A new generation of Ca²⁺ indicators with greatly improved fluorescence properties. J.Biol.Chem., 1985;260:3440 PMID: 3838314
Wang et al. Sildenafil inhibits human pulmonary artery smooth muscle cell proliferation by decreasing capacitative Ca²⁺ entry. J.Pharmacol.Sci., 2008;108:71 PMID: 18818482