L 012 sodium salt

Name: L 012 sodium salt
Brand: Tocris Bioscience
SKU: 5085

Tocris Bioscience, part of Bio-Techne | Catalog # 5085

Citations (4)

COA / SDS

Chemiluminescent ROS and RNS indicator

Key Product Details

Chemical Name:	8-Amino-5-chloro-2,3-dihydro-7-phenyl-pyrido[3,4-d]pyridazine sodium salt
Purity:	≥98%

View Full Technical Details for L 012 sodium salt

Technical Data
Citations

Biological Activity for L 012 sodium salt

L 012 sodium salt is a luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Active in vitro and in vivo.

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer

Technical Data for L 012 sodium salt

Formula	C₁₃H₈CIN₄NaO₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	143556-24-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L 012 sodium salt

Solubility

Soluble Soluble to 20 mM in water and to 100 mM in DMSO

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for L 012 sodium salt

References are publications that support the biological activity of the product.

Kielland et al. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic.Biol.Med., 2009;47:760 PMID: 19539751
Zhou et al. Noninvasive assessment of localized inflammatory responses. Free Radic.Biol.Med., 2012;52:218 PMID: 22080048
Ichibangase et al. Evaluation of lophine derivatives as L-012 (luminol analog)-dependent chemiluminescence enhancers for measuring horseradish peroxidase and H2 O2. Luminescence., 2013;29:118 PMID: 23630098