Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate
R&D Systems, part of Bio-Techne | Catalog # ES001
Substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, Cathepsin D, and Cathepsin E
Key Product Details
Conjugate
7-Methoxycoumarin
Applications
Binding Activity, Bioactivity
Product Specifications
Source
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
Mca: (7-Methoxycoumarin-4-yl)acetyl, Dpa: N-3-(2, 4-Dinitrophenyl)-L-2,3-diaminopropionyl.
Predicted Molecular Mass
1093 Da
Activity
The peptide substrate contains a highly fluorescent
7-methoxycoumarin group that is efficiently quenched by resonance energy
transfer to the 2, 4-dinitrophenyl group. It can be used to measure the
activities of peptidases that are capable of cleaving an amide bond between the
fluorescent group and the quencher group, causing an increase in fluorescence.
It is also an excellent substrate for active Cathepsins D and E.
It is also an excellent substrate for active Cathepsins D and E.
Formulation, Preparation and Storage
ES001
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light. |
Background: Protease Substrates
Additional Protease Substrates Products
Product Documents for Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate
Product Specific Notices for Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate
For research use only
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